Leptin gene variants and colorectal cancer risk: Sex-specific associations.

PLoS One · 2018 · PMC6209341 · PMID 30379922

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an increasing trendno p-value reported

reported an increasing trend in leptin levels for each addition of the C minor allele in LEP rs4731426 [ 24 ].

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borderline significantno p-value reported

Unlike with EO HRT use at baseline, associations of leptin variants with CRC risk were statistically significant among both users and non-users of EP HRT at baseline, and the association of both variants with CRC risk was only borderline significant among never users.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.