borderline significanceP = 0.051
In subgroup analyses by family history, AA carriers had a significant decreased risk compared with GG carriers in those with family history (AA vs GG: OR = 0.68, 95% CI , 0.47–0.98, P = 0.039), and a borderline significance was found for AA vs GG + GA ( OR = 0.70, 95% CI , 0.48–1.00, P = 0.051).