APOE4 Genotype Exerts Greater Benefit in Lowering Plasma Cholesterol and Apolipoprotein B than Wild Type (E3/E3), after Replacement of Dietary Saturated Fats with Low Glycaemic Index Carbohydrates.

Nutrients · 2018 · PMC6213759 · PMID 30336580

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This finding, together with the highly significant and previously established characteristic of plasma LDL-C being elevated in E4 carriers and lower in E2 carriers relative to E3/E3, is consistent with this polymorphism exerting a significant impact on variation in plasma cholesterol in populations [ 8 ].

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