The Importance of the Right Framework: Mitogen-Activated Protein Kinase Pathway and the Scaffolding Protein PTPIP51.

Int J Mol Sci · 2018 · PMC6213971 · PMID 30360441

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highly significantno p-value reported

Application of several EGFR/Her2 targeted TKIs to the Her2 amplified breast cancer cell line SK-BR3 led to a highly significant augmentation of PTPIP51/c-Src interaction, whereas the same treatment of BT474 cells, also a Her2 amplified breast cancer cell line, did not alter or even reduce the PTPIP51/c-Src interaction.

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