Sub-Chronic Stress Exacerbates the Pro-Thrombotic Phenotype in BDNF^Val/Met Mice: Gene-Environment Interaction in the Modulation of Arterial Thrombosis.

In addition, although sub-chronic RS induced a decreasing trend in BDNF expression in both BDNF Val/Met and BDNF Val/Val , the reduction was significant only in BDNF Val/Val suggesting that the reduction of BDNF in arterial tissue is possible only to a certain threshold level, supporting its fundamental role in the vascular physiology [ 45 , 46 , 47 ].

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