70 - 74 In one study, R 1 groups were examined and, owing to different R 1 moiety, the difference in the affinities with hydroxyapatite was almost insignificant. 75 When the R 2 groups were studied, it was found that the affinities of different bisphosphonates related to different R 2 groups in the order of zoledronate > alendronate > ibandronate = risedronate > etidronate.
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Anabolic and antiresorptive actions of locally delivered bisphosphonates for bone repair: A review.
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