highly significantp < 0.001
Two highly significant ( p < 0.001) molecular signatures were identified by Gene Set Enrichment Analysis of BAP1 calling-card target genes associated with gene expression response to BAP1 depletion (see Additional file 7 ): an Epithelial-to-Mesenchymal Transition (EMT) signature was associated with up-regulated genes; and a polycomb-mediated lysine27-trimethylation of histone H3 in Embryonic Stem Cells was associated with down-regulated genes (Fig. 4d ).