A recent large study using the pooled PORTEC biobank in which LVSI was quantified and graded as absent, mild (a single focus or few foci) or substantial (diffuse or multifocal) showed that substantial LVSI is a highly significant risk factor for pelvic and distant recurrence 14 .
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Ten-year results of the PORTEC-2 trial for high-intermediate risk endometrial carcinoma: improving patient selection for adjuvant therapy.
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