Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis.

FASEB J · 2018 · PMC6219823 · PMID 29920219

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highly significantno p-value reported

The activity of proteases, including the aggrecan proteoglycan-degrading aggrecanases, members of the a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family and collagenase members of the matrix metalloproteinase (MMP) family, are highly significant in arthritis ( 6 , 7 ).

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