Combination of Coenzyme Q₁₀ Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model.

Moreover, the combined treatment promoted a highly significant increase in the expression of proteins involved in mitochondrial biogenesis, such as PGC-1 α (+284.9%, p < 0.0001) and SIRT5 (+39.5%, p = 0.02), compared to sedentary mice ( Figure 7 ).

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