Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches.

Molecules · 2018 · PMC6222541 · PMID 30126100

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highly significantno p-value reported

[ 41 ] represented a highly significant step forward, in that it provided the first conclusive evidence that AML-associated oncogenes derived from MLL rearrangements; in this case, MLL-ENL and MLL-AF9-could transform human primitive hematopoietic cells as a single hit and confer on them leukemogenic properties.

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