Effects of Intensive Systolic Blood Pressure Lowering on Cardiovascular Events and Mortality in Patients With Type 2 Diabetes Mellitus on Standard Glycemic Control and in Those Without Diabetes Mellitus: Reconciling Results From ACCORD BP and SPRINT.

The reasons for the lack of statistical significance between the primary composite CVD end point in the ACCORD BP trial intensive versus standard SBP treatment arms 9 remain widely debated, given the highly significant findings observed in SPRINT. 11 A participant‐level pooled meta‐analysis of SPRINT and ACCORD BP participants suggested that in the combined cohort, intensive SBP lowering decreased the risk of CVD events. 19 These results, however, were primarily driven by the SPRINT data. 19 Differences in blood pressure measurement techniques, 20 differences in the achieved SBP separations, 21 and differences in selection criteria 22 have also been proposed as potential explanations.

also in 132,142 other papers