Systematic Review and Meta-analysis of Short- versus Long-Acting Granulocyte Colony-Stimulating Factors for Reduction of Chemotherapy-Induced Febrile Neutropenia.

Six non-RCT publications reported no significant difference between short- and long-acting G-CSFs [ 23 , 27 – 29 , 38 , 41 , 50 ], five reported that pegfilgrastim was significantly superior to filgrastim [ 10 , 13 , 14 , 18 , 54 ], one reported a numerical trend toward this result but did not perform a statistical analysis [ 21 ], and one reported that filgrastim was significantly more effective than pegfilgrastim [ 32 ].

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