Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.

The effects of the PRSs for BPH/LUTS and prostate cancer on PSA levels are largely independent since, in a joint analysis the effect of both remained highly significant, i.e. 8.6% increase ( P = 3.0 × 10 −20 ) and 13.3% increase ( P = 4.1 × 10 −43 ), respectively (Table 2b ).

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