RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade.

Mol Ther · 2018 · PMC6225018 · PMID 30274786

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highly significantno p-value reported

While the irrelevant DsiRNA placebo had no significant effect on the tumor immune compartment, DCR-BCAT treatment resulted in highly significant increases in total T cells (CD3), cytotoxic T cells (CD8), antigen-presenting dendritic cells (CD103), and the PD-1 T cell checkpoint.

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