Ferrocene-Containing Impiridone (ONC201) Hybrids: Synthesis, DFT Modelling, In Vitro Evaluation, and Structure⁻Activity Relationships.

It is of note that in the 1 H-NMR spectra of 7gb , 7gc , 7gh , and 7gi , the planar chiral 2-iodoferrocenyl moiety in R 1 causes highly significant AX-type split on the signal of H-6 protons (∆δ = 0.24 ppm for each), while no separation of N7-CH 2 signal is discernible in spite of the close neighbourhood of the planar chiral element. 2.3.

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