highly significantp < 0.01
In contrast, mutants JFH1-CErep-S1, JFH1-CErep-S1/L and JFH1-CErep-S1/L/R, in which miR122 binding to S1 is blocked, all showed a >10-fold, highly significant reduction in the level of replication ( p < 0.01) ( Fig. 6D ).
In contrast, mutants JFH1-CErep-S1, JFH1-CErep-S1/L and JFH1-CErep-S1/L/R, in which miR122 binding to S1 is blocked, all showed a >10-fold, highly significant reduction in the level of replication ( p < 0.01) ( Fig. 6D ).