These effects were judged to be secondary to a failure to dephosphorylate and inhibit protein kinase C isoforms, a prerequisite for the timely activation of Cdk1/CycB and are likely to be significant as both male and female mice lacking DUSP7 /MKP-X have been reported as viable but infertile ( http://www.mousephenotype.org/data/genes/MGI:2387100 ).
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