For both cis- and trans- methylation, the typical outcome followed an expected trend, where mC/oxoG clustering narrowed imino proton lines with respect to oxidized only CpG guanines and broadened imino proton lines with respect to methylated only CpG guanines (Figure 4 , Supplementary Figure S9 ).
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Oxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation.
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