Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls.

In our previous experiments 20 , we found a highly significant reduction of age-adjusted TL in peripheral blood lymphocytes of high-level PCB exposed individuals (∑ indicator PCBs up to 236 μg/L plasma 21 ) where a dependency of telomere shortening on the exposure level of LC PCBs could be shown.

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