Few studies have assessed steroid hormone effects on the incidence of DCIS in postmenopausal women; however, a retrospective study of the WHI trial found a trend towards significance of higher incidence in a large cohort of women with no prior hysterectomy that were administered CEE and MPA compared to the placebo arm [ 33 ].
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The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast.
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