A preliminary pharmacokinetic study of betulin, the main pentacyclic triterpene from extract of outer bark of birch (Betulae alba cortex).

Molecules · 2008 · PMC6245357 · PMID 19104487

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highly significantno p-value reported

Within 1, 2 or 4 h on test day 1, a significant or highly significant increase of BE concentration in comparison to the value after 0.5 h was observed in all three dose level groups.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.