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Saccharomyces cerevisiae adapted to grow in the presence of low-dose rapamycin exhibit altered amino acid metabolism.

Cell Commun Signal · 2018 · PMC6245637 · PMID 30458881

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a decreasing trendno p-value reported
The final biomass density of the ab initio treated cultures did not demonstrate an increasing or a decreasing trend as the rapamycin concentration of the medium was increased from 20 nM to 400 nM.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.