Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin.

46 – 48 The mMCP4 −/− mice did not differ significantly from the controls at any 5-min interval, but a slight trend toward higher pain responses during the last 15 min of the formalin test was observed; at 45–50 min, they demonstrated 124.0 ± 17 s of pain behavior versus 69.5 ± 20 s for controls ( Figure 1(a) ).

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