Moreover, in characterizing members of the ERK/CREB/BDNF pathway in the hippocampi of rats infected with both BDV strains, we found that p-ERK1/2 was upregulated (Strain V- and Hu-H1-infected rats vs control rats) and other signaling molecules either increased (p-90RSK and p-MSK1 in Hu-H1-infected rats vs control rats, P <0.05; p-c-Raf in Strain V-infected rats vs control, P <0.05) or showed an increasing trend (p-MEK1/2, p-CREB, CREB, and BDNF).
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Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats.
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