The Contribution of Purifying Selection, Linkage, and Mutation Bias to the Negative Correlation between Gene Expression and Polymorphism Density in Yeast Populations.

Partial correlations controlling for gene expression were also highly significant in this case ( S. cerevisiae : rho= − 0.13, P = 4.38 · 10 −11 , n = 2,432; S. pombe: rho= − 0.12, P = 2.91 · 10 −18 , n = 5,069).

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pombe , we detected a weak trend in the opposite direction which probably resulted from a bias in the GC content.

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