highly significantP < 0.0001
This study did not show a benefit in OS (adjusted HR 0.78, 95% CI.0.56–1.08; P = 0.13), but did reveal a highly significant improvement in PFS, with 5 year PFS of 47.6 vs. 31.8% for those given immediate adjuvant chemotherapy (HR: 0.54, 95% CI: 0.40–0.73, P < 0.0001).