Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

Moreover, in the present study we have detected a number of transethnic SNPs in the 12q24 region to show highly significant heterogeneity of genetic impact on SBP between the ethnic groups (e.g., β EAS = −0.73 and β EUR = 0.37, P het = 9.74×10 –21 at rs4766566), where inverted genetic effects are attributable to each of the ancestry-specific sentinel SNPs; a similar situation was also observed on 10q21 to reproduce this phenomenon (Fig. 1 and Supplementary Data 6 ).

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