Novel substituted heteroaromatic piperazine and piperidine derivatives as inhibitors of human enterovirus 71 and coxsackievirus a16.

The compounds with the alkoxy, ester, or alkyl group at position 4 of the phenoxyl ring (compounds 8a – f and 9g – h ) revealed that the suitable steric volume, neither too large nor too small, may be significant for anti-CVA16.

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