3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors.

Molecules · 2014 · PMC6270810 · PMID 24603555

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highly significantno p-value reported

The CB1 receptors are expressed fundamentally in the central nervous system (CNS) and they are the most abundant GPCRs in the brain, with levels 10-fold higher than those of other GPCRs [ 7 ], indicating a highly significant functional role in a wide variety of circuits and neuronal systems [ 8 ].

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