ImageJ quantification confirmed that OMA1+/+ cells showed highly significant decreases in L-OPA1 in response to H 2 O 2, while OMA1−/− cells showed no difference in L-OPA1 levels between untreated controls and H 2 O 2 -treated samples ( Figure 4 (F)).
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Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells.
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