The molecular progression detailed here in single fiber cells suggests that the process of differentiation in the ocular lens starts and ends with similar transcriptional profiles; it is highly significant that the two are connected via highly heterogeneous gene activity, which may appear “stochastic” and yet culminate in phenotypically relevant expression.
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Spatial Analysis of Single Fiber Cells of the Developing Ocular Lens Reveals Regulated Heterogeneity of Gene Expression.
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