MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20.

Nat Commun · 2018 · PMC6277393 · PMID 30510186

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highly significantno p-value reported

However, cells expressing H2B K20R showed a dramatic and highly significant reduction in their ability to activate SASP gene transcription in response to senescent cell-generated conditioned media.

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