Loss of the candidate tumor suppressor ZEB1 (TCF8, ZFHX1A) in Sézary syndrome.

Results GISTIC analysis of somatic DNA copy-number alterations in Sézary syndrome identified ZEB1 gene as the target of a highly significant focal deletion of 10p11.22 We used SNP 6 arrays and GISTIC2.0 algorithm to identify genes targeted by focal SCNAs, likely representing candidate “drivers” for cancer growth 26 , 29 , in a dataset composed of 33 samples, collected at different time points, from 21 SS patients and 3 CTCL cell lines (Hut78, H9, HH).

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