There was only a marginally significant difference in CFU-G, and slight reduction in CFU-M, but consistent with studies of fetal livers, results show marked decreases in CFU-Mk and CFU-E formation in chromosome 21 silenced samples of transgenic subclones, (Fig. 5a ).
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Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro.
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