Metformin Administration During Early Postnatal Life Rescues Autistic-Like Behaviors in the BTBR T+ Itpr3tf/J Mouse Model of Autism.

Although the difference was not significant (Figure 7B , P = 0.057), a decreasing trend of S6K mRNA levels was observed after metformin treatment in BTBR mice (Figure 7B , main effect of drug: F (1,12) = 0.629, P = 0.443; main effect of genotype: F (1,12) = 11.435, P < 0.01; drug × genotype effect F (1,12) = 4.780, P < 0.05).

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