Role of Helicobacter pylori infection in cancer-associated fibroblast-induced epithelial-mesenchymal transition in vitro.

We have also noticed a highly significant increase in mRNA expression of COX‐2 and IL‐8 in cells infected with H. pylori (cagA+vacA+) strain (Figure 2 A). 3.3 EMT inducers, ECM components, and proinvasive signals The mRNA expression for TGFβ and scattering factor HGF was significantly increased at 72 hours of coincubation with H. pylori (cagA+vacA+) over those observed in control fibroblasts (Figure 2 A).

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