The novel atypical antipsychotic cariprazine demonstrates dopamine D<sub>2</sub> receptor-dependent partial agonist actions on rat mesencephalic dopamine neuronal activity.

CNS Neurosci Ther · 2018 · PMC6282959 · PMID 29729086

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0.0619

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0.0619

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almost significantlyP = .0619so close (0.05 < p ≤ 0.1)

In contrast, while the systemic administration of PD 128,907 (10 μg/kg, i.v.) completely suppressed the bursting activity of DA neurons (data not shown), only L741,626 significantly reduced the suppressant effect of PD 128,907 on bursting activity in these cells in the VTA (bursting remaining of 25.8 ± 13.1%, P < .01) and almost significantly in the SNc (bursting remaining of 21.2 ± 14.6%, P = .0619).

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