Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.

PLoS Negl Trop Dis · 2018 · PMC6283605 · PMID 30475806

Europe PMC DOI

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closest p · 0.0× alpha

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highly significantP = 2.3 × 10 −9actually significant

A prior RNA interference (RNAi) Target Sequencing (RIT-seq) screen revealed a highly significant ( P = 2.3 × 10 −9 ) over-representation of kinases, comprising three hits among the top seven in this screen; these were a putative mitogen-activated protein kinase (MAPK11, Tb927.10.12040), a putative MAPK kinase (MKK4, Tb927.8.5950) and a putative MAPK kinase kinase (STE11, Tb927.10.1910) [ 14 ].

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