Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge.

This analysis revealed a class of highly significant motifs correlated with open chromatin that were common to both host and graft cells and a variety of other myeloid cells ( p < 10e−20) such as CTCF, SPI1, and Runx binding motifs (Supplementary Fig. 7b ).

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