Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging.

MAbs · 2018 · PMC6284555 · PMID 30199303

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A slight trend towards reduced antibody distribution was observed for 7C2-TCO 6 compared to 7C2 in tumor (9.9 vs 10.7 %ID/g, p > 0.05), liver (2.6 vs 3.8 %ID/g, p > 0.05) and spleen (3.9 vs 7.8 %ID/g, p < 0.05) despite equivalent systemic exposure ( Figure 4A ).

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