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Assessing health-related quality of life of patients with colorectal cancer using EQ-5D-5L: a cross-sectional study in Heilongjiang of China.

BMJ Open · 2018 · PMC6286482 · PMID 30530472

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a decreasing trendno p-value reported
We found a decreasing trend in HRQoL with the progress of CRC, consistent with those reported in Australia and some European countries. 26 39–41 However, CK Wong and colleagues reported worse HRQoL in patients with stage II CRC compared with those in stage III and IV. 18 Patients with CRC undergoing surgical procedures often have lower HRQoL. 26 42 Our study provides additional evidence for this conclusion.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.