Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease.

The nuclear ancestry was statistically different between the alleles of seven of the eight SNPs assessed by chi-squared test; m.1438, m.3197, m.4769, m.10398 and m.15043 were statistically highly significant (P-value = 2.6e -7 , 1.34e -6 , 2.45e -7 , 2.2e -16 2.2e -16 respectively) and m.3666 and m15218 were statistically significant (P-value = 0.002 and 0.008 respectively whereas m.9377 was not statistically different.

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