Precise Dissolution Control and Bioavailability Evaluation for Insoluble Drug Berberine via a Polymeric Particle Prepared Using Supercritical CO₂.

Polymers (Basel) · 2018 · PMC6290634 · PMID 30961123

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a decreasing trendno p-value reported

Interestingly, the solubilities of all samples except ICB showed maximum values within the first 2 min and a decreasing trend with time.

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