Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging.

Front Immunol · 2018 · PMC6290897 · PMID 30568654

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a notable trendno p-value reported

Also, there is a notable trend of lower analyte release of γδ T cells from the older compared with younger uninfected subjects, and a converse trend of increased analyte secretion with older age within the HIV+ subject group.

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a positive trendno p-value reported

Conversely, the percentage of TIGIT+ γδ T cells from the ART-suppressed HIV+ subjects positively and significantly correlated with the secretion of five analytes: sCD137, Granzyme A, Granzyme B, MIP1-β, and CCL20/MIP3-α and showed a positive trend for others such as perforin, TNF-α, and IFN-γ (Figures 4B,C ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.