The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage.

p ≤ 0.05 was considered statistically significant (*) and p ≤ 0.001 extremely significant (***). p > 0.05 was considered not significant (ns). 10.7554/eLife.40856.047 Decision letter Zhang Hong Reviewing Editor Institute of Biophysics, Chinese Academy of Sciences China In the interests of transparency, eLife includes the editorial decision letter and accompanying author responses.

also in 7,787 other papers

However, WT RAW264.7 cells exhibited a sustained and much higher degree of detectable Caspase-3 after prolonged etoposide treatment for 16 and 24 hr, which was highly significant at 16 hr ( Figure 7A and B ; numerical values Figure 7—source data 1 ), suggesting that TFE3 and TFEB are critical for the proper induction of DNA damage induced apoptosis.

also in 132,142 other papers