Variants of <i>DNMT3A</i> cause transcript-specific DNA methylation patterns and affect hematopoiesis.

Notably, DNMT3A2 -exon expression in AML patients revealed a highly significant correlation with DNAm levels at CpGs that were hyper- and hypomethylated upon KD of transcript 2 in vitro ( P < 10 −100 and P = 2 × 10 −37 , respectively; Fig 4B ).

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