Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery.

For both the baseline and DA-stimulated results, highly significant, replicated enrichments were observed in the pair of matching brown modules: GO-term “SRP-dependent co-translational protein targeting to membrane”, representing 42.3% and 70.6% of the genes, respectively (FDR = 4.0 × 10 −141 and 2.7 × 10 −161 ); and KEGG pathway “Ribosome”, representing 40.7% and 68.8% of the same genes (FDR = 2.3 × 10 −110 and 1.1 × 10 −125 ).

also in 132,142 other papers