Particularly in settings with a high disease burden among older individuals, as in most high-income countries, the indirect effect of vaccination on adult pneumococcal disease is likely to be significant. 36 In conclusion, our results show large benefits of PCV use worldwide in terms of lives saved and disability averted, and in terms of cost-effectiveness, particularly in Africa and Asia.
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Effect and cost-effectiveness of pneumococcal conjugate vaccination: a global modelling analysis.
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