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Bibliometric Study of Obstetrics Articles Published in the Journal of the American Medical Association, 1997-2016.

Cureus · 2018 · PMC6294270 · PMID 30555763

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an increasing trendno p-value reported
This chronological change could be partly explained by the fact that the number of articles on HIV infection were steadily decreasing, whereas there was an increasing trend in those on infertility and pregnancy complications in women of advanced age.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.